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Louisville notched another blowout win in Week 10 and is in full control of its ACC Championship destiny.

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College Football Week 11 Virginia vs. Louisville odds preview

The Cardinals took it to Virginia Tech in a 34-3 beatdown, but it wasn’t a typical Louisville victory. Jack Plummer and a hobbled Jawhar Jordan had modest performances, and it was Isaac Guerendo who had a monster day that led the Cardinals to a win.

Guerendo got 11 carries for 146 yards and three touchdowns, surpassing his previous game-high of 63 yards in Week 2. As Jordan works to get healthy while dealing with a hamstring injury, Louisville fans learned the Cardinals have strong RB depth thanks to Guerendo’s big day.

The Cardinals look to sweep the Virginia ACC schools with a Week 11 triumph. The Cavaliers are 2-7, but shouldn’t be taken lightly. Virginia upset No. 10 North Carolina and fell short against Miami by a field goal in overtime.

Virginia vs. Louisville best bets and odds: Under 50.5 (-110 or better)

Louisville’s defense has been next level in the past two games, allowing only three points and 342 total yards. This has taken the pressure off the Cardinals’ offense, which has also been dominant.

Virginia ranks third-worst in the ACC in points scored per game and is dead last in points allowed, likely leading to another big win for Louisville. The Cardinals -20.5 is an enticing wager, but given how Virginia competed against North Carolina and Miami, the under is seemingly the safer play.

Virginia vs. Louisville best bets and odds: Jack Plummer under 205.5 passing yards (-115 or better)

The Cardinals’ last two decisive victories followed similar offensive game plans: run the damn ball. Louisville rushed 48 times in the win over Duke, and 38 times in the Virginia Tech victory.

Plummer had only 28 total pass attempts in those games, and it’s likely Jeff Brohm will deploy a similar approach vs. Virginia. Especially with the emergence of Guerendo, giving the Cardinals another solid RB to lean on if Jordan is limited once again.

If it ain’t broke, don’t fix it.

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