The New York Giants face an uphill battle without Saquon Barkley when they the San Francisco 49ers Thursday, Sept. 21. The game will be live streamed on Amazon Prime (free trial).

Matching the biggest comeback win in franchise history was cause for celebration for the New York Giants.

But they know it won’t be nearly as easy climbing out of a big hole this week when they take on the powerhouse San Francisco 49ers (2-0) on Thursday night as it was against the bottom-dwelling Arizona Cardinals.

Accomplishing that for the Giants (1-1) will be a lot harder without star running back Saquon Barkley, who will miss at least this week’s game after spraining his ankle late in the win against Arizona.

That puts even more pressure on quarterback Daniel Jones to play the way he did in the second half against Arizona and not like the first six quarters of the season.

The Giants didn’t do that to start the season. They got off to one of the worst starts in recent history in the NFL, losing the opener 40-0 to Dallas and then falling behind 20-0 at the half to the Cardinals and 28-7 in the third quarter.

New York was the first team in 45 years to allow at least 60 points before scoring for the first time in a season. The Giants then scored 31 points in the second half behind 317 yards of offense and three TDs from Jones.

When is Giants-Niners game?

The New York Giants and San Francisco 49ers play at 7:15 p.m. (8:15 p.m. ET) on Thursday, Sept. 21.

Will it be live streamed?

The game will be live streamed on Amazon Prime, which offers a free trial. Prime Video is included with an Amazon Prime membership. You can also sign up for Prime Video as a standalone service for $14.99 monthly. Don’t have a Prime membership? Amazon offers a 30-day free trial.

What TV channel is game on?

The Niners-Giants will not be broadcast on traditional television.

The Associated Press contributed to this report.