For the third time in as many weeks, Auburn will head into an SEC game as the underdog.

Fresh off a 42-10 blowout at the hands of rival Georgia, in what was Auburn’s first road test of the season, Bryan Harsin’s squad will try to rebound in its second straight road game — an 11 a.m. matchup against No. 9 Ole Miss in Week 7. The Tigers (3-3, 1-2 SEC) opened as 13.5-point underdogs against the Rebels (6-0, 2-0), according to VegasInsider.com.

Read more Auburn football: Bryan Harsin left searching for answers, “hope” after loss to Georgia

Bryan Harsin justifies failed fake punt attempt against Georgia

Scarbinsky: Auburn will be hopeless and helpless until it is Harsin-less

That’s the largest point spread in favor of Ole Miss in the series in more than two decades. The last time Auburn met Ole Miss as a two-score underdog was in 2001, when the Rebels were favored by 14 points, according to OddsShark data. Auburn won that game, 27-21, in Jordan-Hare Stadium.

Auburn has largely dominated Ole Miss in the SEC West rivalry, particularly of late while winning six straight games against the Rebels. The Tigers’ last loss in the series was in 2015 on the Plains; they haven’t lost in Oxford, Miss., since the dreaded 2012 season, though that win was among the 33 overall vacated by Ole Miss between 2010 and 2016.

Auburn holds an overall series lead of 35-11 against Ole Miss, including a 13-3 record in Vaught Hemingway Stadium. The Tigers have not been road underdogs in the series since 2014, when the two teams met in a top-10 clash, with the Rebels a slight favorite on their home turf. Auburn won that game, 35-31.

The Tigers are 1-5 against the spread this season, only covering in their Week 5 loss to LSU. The Rebels, meanwhile, are 3-3 against the spread. The teams will meet at 11 a.m. Saturday, with the game airing on ESPN.

Tom Green is an Auburn beat reporter for Alabama Media Group. Follow him on Twitter @Tomas_Verde.